13 May 1998 Morphological studies of metastatic mammary rat tumors after laser immunotherapy treatment
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Proceedings Volume 3254, Laser-Tissue Interaction IX; (1998) https://doi.org/10.1117/12.308195
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States
Laser immunotherapy, using a combination of 805 nm diode laser, photosensitizer indocyanine green and immunoadjuvant glycated chitosan, has shown an induced anti-tumor immune response in treatment of metastatic rat tumors. In additional to an apparent systemic, long-term humoral immunological reaction, there could also be laser induced local cellular immune responses. A morphological study was performed to study the immune cells and their infiltration to tumor tissue after this laser immunotherapy treatment. Tumor-bearing rats were terminated at designated times after the treatment; both the tumor and the surrounding normal tissue were collected. The tissue samples were observed under electron microscope. The number and types of infiltrating cells at the tumor site were studied after treatment to determine the contribution of these cells in the elimination of tumors. The tumor cell structural changes resulted from laser-tissue photothermal interaction was investigated. The morphology of tumor development and activities of immune cells including both lymphocytes and plasma cells could shed light on the mode of action of laser treatment of tumors.
© (1998) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Robert E. Nordquist, Robert E. Nordquist, John A. Nordquist, John A. Nordquist, James C. Agee, James C. Agee, Chad M. Blomquist, Chad M. Blomquist, Wei R. Chen, Wei R. Chen, } "Morphological studies of metastatic mammary rat tumors after laser immunotherapy treatment", Proc. SPIE 3254, Laser-Tissue Interaction IX, (13 May 1998); doi: 10.1117/12.308195; https://doi.org/10.1117/12.308195

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