24 April 1998 Probing diseased skin with FT-Raman spectroscopy
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Proceedings Volume 3257, Infrared Spectroscopy: New Tool in Medicine; (1998) https://doi.org/10.1117/12.306085
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States
Abstract
Healthy and abnormal human skin has been examined using Fourier transform (FT) Raman spectroscopy. The molecular basis of alternations in this tissue have been proved with the aim of providing a tool to aid in clinical diagnosis of skin disorders. Intact human stratum corneum show spectral features of keratin and the lipids. Spectra from callus and psoriatic tissue show that the keratin component is essentially intact and is similar to that in the normal tissue. However, the abnormal skin shows that the keratin component is essentially intact and is similar to that in the normal tissue. However, the abnormal skin shows a significant depletion of the lipoidal component, which correlates with clinical observations of an increase in permeability and the hyper-proliferative nature of these conditions. Verrucal tissue again shows some alterations to the lipoidal fraction of the tissue.
© (1998) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Elizabeth A. Carter, Elizabeth A. Carter, Adrian C. Williams, Adrian C. Williams, Brian W. Barry, Brian W. Barry, Howell G.M. Edwards, Howell G.M. Edwards, } "Probing diseased skin with FT-Raman spectroscopy", Proc. SPIE 3257, Infrared Spectroscopy: New Tool in Medicine, (24 April 1998); doi: 10.1117/12.306085; https://doi.org/10.1117/12.306085
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