Application of a laser radar photogoniometer in the diagnosis of osteoporosis

Hans-Georg Eberle; Juergen Beuthan; Marc Dierolf; Dieter Felsenberg; Wolfgang Gowin; Gerhard J. Mueller

doi:10.1117/12.307321

10 April 1998 Application of a laser radar photogoniometer in the diagnosis of osteoporosis

Hans-Georg Eberle, Juergen Beuthan, Marc Dierolf, Dieter Felsenberg, Wolfgang Gowin, Gerhard J. Mueller

Proceedings Volume 3259, Systems and Technologies for Clinical Diagnostics and Drug Discovery; (1998) https://doi.org/10.1117/12.307321
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

First results on angle dependent light scattering performed on normal and osteoporotic human bone tissue in vitro are presented. The scattering distributions are measured in cw mode as well as in time-resolved (time-gated) mode. Significant differences in the angular distribution of 675 nm laser radiation transmitted through normal or osteoporotic bones are found in cw-scattering measurements. For aspiring in situ results the transition in time-resolved measurements is needed to suppress the disturbing soft tissue signals. In this way, a characterization of the bone part is aimed by selectively recording the scattered signal in a suitable chosen time window. The measurement's principle is based on time-correlated single photon counting using a 10 ps laser diode (830 nm) and a micro channel plate- photomultiplier tube. First in vitro results on human lumbar vertebrae (L1) obtained with this equipment show a correlation between the thermal peak position and the FWHM of the scattered light pulses and the bone mineral densities determined by Dual X-ray absorptiometry. The angle dependent scattering curves give distinct indications on the bone status in transmission mode.

Citation Download Citation

Hans-Georg Eberle, Juergen Beuthan, Marc Dierolf, Dieter Felsenberg, Wolfgang Gowin, and Gerhard J. Mueller "Application of a laser radar photogoniometer in the diagnosis of osteoporosis", Proc. SPIE 3259, Systems and Technologies for Clinical Diagnostics and Drug Discovery, (10 April 1998); https://doi.org/10.1117/12.307321

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