Cancer diagnostics using Fourier transform fiber optic infrared evanescent wave spectroscopy (FTIR-FEWS)

Juergen Spielvogel; Leonid Lobik; Israel Nissencorn; Raimund Hibst; Yaron Gotshal; Abraham Katzir

doi:10.1117/12.309482

5 June 1998 Cancer diagnostics using Fourier transform fiber optic infrared evanescent wave spectroscopy (FTIR-FEWS)

Juergen Spielvogel, Leonid Lobik, Israel Nissencorn, Raimund Hibst, Yaron Gotshal, Abraham Katzir

Proceedings Volume 3262, Surgical-Assist Systems; (1998) https://doi.org/10.1117/12.309482
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

A Fourier transform IR spectrometer and IR transmitting AgClBr fibers were used for fiberoptic evanescent wave spectroscopy (FTIR-FEWS) of cancer. Malignant and healthy tissue samples were extracted from patients at the Meir Hospital in Israel, placed on a Silver Halide fiber, and measured using the FTIR-FEWS system. The IR spectra were analyzed and compared by taking the ratio of absorption of the active functional groups of Amide I at 1642 cm^-1 and Amide II at 1545 cm^-1. Clear differences appeared between the two types of tissue. When placing the tissue samples on bare fiber the reproducibility of the result was not satisfactory due to chemical interaction between the tissue and the fibers. This problem was solved by applying Polyethylene coating of thickness 1-2 μm on the fiber, leading to reproducible results. The results of these preliminary studies indicate that eh FTIR-FEWS technique can be used for cancer diagnostics. Combined with endoscopy this technique could be used to analyze tissues inside the body in vivo and in real time.

Citation Download Citation

Juergen Spielvogel, Leonid Lobik, Israel Nissencorn, Raimund Hibst, Yaron Gotshal, and Abraham Katzir "Cancer diagnostics using Fourier transform fiber optic infrared evanescent wave spectroscopy (FTIR-FEWS)", Proc. SPIE 3262, Surgical-Assist Systems, (5 June 1998); https://doi.org/10.1117/12.309482

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