1 January 1998 Preparation and characterization of Langmuir- and Langmuir-Blodgett layers of mixed skin lipids
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Abstract
The lipids of the stratum corneum fulfil a vital barrier function for the mammalian body. Cermides IV and cholesterol as the main components of stratum corneum as well as their mixtures have been investigated using Langmuir method at the air-water interface. Different 2D phases have been characterized by the aid of (Pi) /A isotherms and by fluorescence micrographs. The properties of films strongly depend on the composition of the mixtures. The Langmuir- Blodgett technique (LB) has been used for the preparation of supported monolayers. These LB layers have been investigated by atomic force microscopy and cyclic voltammetry. It could be shown that addition of small amounts of cholesterol to ceramides IV results in an improvement of the properties of the films: a decrease of electrical capacity of the layer and a decrease of the defect density of the film. In a film containing 50 mol percent ceramides IV an increase of the capacity and phase separation in the surface film has been observed.
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H. Schaffer, U. Bakowsky, T. Martini, Wolfgang Rettig, Horst Kresse, "Preparation and characterization of Langmuir- and Langmuir-Blodgett layers of mixed skin lipids", Proc. SPIE 3319, Liquid Crystals: Chemistry and Structure, (1 January 1998); doi: 10.1117/12.301317; https://doi.org/10.1117/12.301317
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