24 June 1998 Image-guided MR spectroscopy VOI localization for longitudinal studies
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Abstract
Longitudinal magnetic resonance spectroscopy (MRS) studies require accurate repositioning of the volume of interest (VOI) over which measurements are made. In this work we present and evaluate a method for the image-guided repositioning of brain volumes of interest. The point-based registration technique we developed allows the repositioning to be performed on-line (i.e., while the patient is in the scanner). MR image volumes were acquired from six subjects, three scans each over the course of a month. During the first scan, two spectroscopy VOIs are visually selected: one in the frontal white matter, the other in the superior cerebellar vermis. The coordinates of 13 internal brain landmarks were also identified. During both subsequent scans, the same 13 landmarks were also identified, and the transformation that registers the first set of landmarks to the subsequent set is compared. This result is used to automatically map the position of the spectroscopy. VOIs from the first volume to the current volume. For the six subjects evaluated to date, we show an average repositioning error of the spectroscopy VOIs in the order of 1 mm. This accuracy allows us to conclude that any variation in the MR spectra are unlikely to be due to repositioning error.
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Steven L. Hartmann, Steven L. Hartmann, Benoit M. Dawant, Benoit M. Dawant, Mitchell H. Parks, Mitchell H. Parks, Heide Schlack, Heide Schlack, Peter R. Martin, Peter R. Martin, } "Image-guided MR spectroscopy VOI localization for longitudinal studies", Proc. SPIE 3338, Medical Imaging 1998: Image Processing, (24 June 1998); doi: 10.1117/12.310916; https://doi.org/10.1117/12.310916
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