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24 June 1998 Improved SPECT reconstruction of Tc-99m sestamibi distribution in breast tissue
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This paper describes a new image reconstruction method to reduce the presence of image artifacts in scintimammography. SPECT data are mathematically modified prior to conventional image processing, followed by an inverse transform, which permits the tomographic visualization of low signals in the presence of large background intensities observed in scintimammography. Images of Tc-99m sestamibi distribution were obtained in a modeled `breast tissue', with a high activity in the `myocardium' as compared to the `breast tissue' (i.e. 20:1). Image reconstruction with the modified algorithm were qualitatively correct and demonstrated the regions of enhanced uptake (lesions) with no evidence of artifacts from the background counts in the heart. Comparison with MRI demonstrated that the hot regions were properly located and correlated with the MRI data. In contrast, a standard (i.e. Filtered Back Projection) reconstruction resulted in streak artifacts in place of `breast tissue' which rendered them clinically useless. This new approach to scintimammography offers the prospect of significantly reducing image artifacts and improving imaging accuracy.
© (1998) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Andrzej Krol, David H. Feiglin, George M. Gagne, Walter Huda, Gwen M. Tillapough-Fay, Bradford J. Hellwig, and Deaver F. Thomas "Improved SPECT reconstruction of Tc-99m sestamibi distribution in breast tissue", Proc. SPIE 3338, Medical Imaging 1998: Image Processing, (24 June 1998);

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