2 November 1998 Combined effects of photodynamic and sonodynamic treatment on experimental skin cancer on C3H mice
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Proceedings Volume 3344, 1997 Shanghai International Conference on Laser Medicine and Surgery; (1998) https://doi.org/10.1117/12.330180
Event: 1997 Shanghai International Conference on Laser Medicine and Surgery, 1997, Shanghai, China
Abstract
In recent years, the effect of ultrasound (US) in combination with porphyrins such as a gallium-porphyrin complex (ATX-70) has been reported in the treatment of experimental cancers. Before clinical application of this method, further studies are needed. The transplanted squamous cell carcinomas (5CC) on C3H/He mice were irradiated by a tunable optical parametric oscillator (OPO) laser light or ultrasound, in the presence of several different photosensitizers. The tumor size and survival of mice after treatment were observed. Furthermore, we compared antitumor effects of combined irradiation of laser light and ultrasound with those of single laser light or ultrasound, in the presence of ATX-70 or a pheoforbide derivative (PH-1126). Besides PH-i 126 and ATX-70, the following sensitizers were tested: Photofrin II (Pf-II), hematoporphyrin oligomer (HpO). 5-aminolevulinic acid (5-ALA) and aluminum phthalocyanine tetrasuiphonate (AIPcS4). In the results, it was good effects of antitumor by the laser light treatment in the case of PH-1126 and AIPcS4, ATX-70, HpO nsd AIPcS4 produced betterantitumor effeets by irradiation with ultrasound. The antitumor effects of combined use of laser fight and ultrasound were stronger than those of single laser light or ultrasound in both cases of PH-i 126 and ATX-70. Key words: OPO laser light, ultrasound, PH-1126. ATX-70
© (1998) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Zhao-Hui Jin, Zhao-Hui Jin, Norio Miyoshi, Norio Miyoshi, Kazumori Ishiguro, Kazumori Ishiguro, Izumi Maruyama, Izumi Maruyama, Isao Sakata, Isao Sakata, Keigo Takaoka, Keigo Takaoka, Takeshi Udagawa, Takeshi Udagawa, Susumu Nakajima, Susumu Nakajima, Keichi Ueda, Keichi Ueda, Fukuda Masaru, Fukuda Masaru, Masanobu Kumakiri, Masanobu Kumakiri, } "Combined effects of photodynamic and sonodynamic treatment on experimental skin cancer on C3H mice", Proc. SPIE 3344, 1997 Shanghai International Conference on Laser Medicine and Surgery, (2 November 1998); doi: 10.1117/12.330180; https://doi.org/10.1117/12.330180
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