Optical properties of normal and carcinomatous human lung tissues at 406.7 ~ 415.4 nm of a violet Kr+ laser

Shusen Xie; Wei Zheng; Qirong Lin; Buhong Li; Zhiwei Huang; Teck-Chee Chia

doi:10.1117/12.330161

2 November 1998 Optical properties of normal and carcinomatous human lung tissues at 406.7 ~ 415.4 nm of a violet Kr⁺ laser

Shusen Xie, Wei Zheng, Qirong Lin, Buhong Li, Zhiwei Huang, Teck-Chee Chia

Author Affiliations +

Proceedings Volume 3344, 1997 Shanghai International Conference on Laser Medicine and Surgery; (1998) https://doi.org/10.1117/12.330161
Event: 1997 Shanghai International Conference on Laser Medicine and Surgery, 1997, Shanghai, China

Abstract

To understand better the optical characteristics of normal and carcinomatous lung tissues in the clinical photodynamic diagnosis and light dosimetry, we measured the effective attenuation coefficient (mu) _eff, absorption coefficient (mu) _s and reduced scattering coefficient at 406.7-415.4 nm. We performed the measurements by using 'Depthometer with Isotropic Fiber-optic Probe' developed by ourselves accurately to measure the fluence rate distributions in the fresh samples during irradiation with a collimated broad beam of a violet Kr⁺ laser. The total diffuse reflectance R_d was also measured by using a flat-cut optical fiber to guide the light into a detector. Some conclusions of adding-doubling method as well as diffusion theory were utilized to derive the optical properties of the measured tissue. The optical penetration depths of normal and adeno-squamous carcinoma human lung tissues are 0.08 mm and 0.32 mm respectively. We believe that it is the first set of data of 6 at 4.6.7-415.4 nm for fresh human lung tissue.

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Shusen Xie, Wei Zheng, Qirong Lin, Buhong Li, Zhiwei Huang, and Teck-Chee Chia "Optical properties of normal and carcinomatous human lung tissues at 406.7 ~ 415.4 nm of a violet Kr⁺ laser", Proc. SPIE 3344, 1997 Shanghai International Conference on Laser Medicine and Surgery, (2 November 1998); https://doi.org/10.1117/12.330161

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KEYWORDS

Tissues

Lung

Optical properties

Tissue optics

Diffuse reflectance spectroscopy

Natural surfaces

Scattering

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