Currently, wide applications of lasers in various disciplines of medicine including urology are well developed. A thorough knowledge of laser use in urinary tract disease is recommended. Low energy GA-LA-AS laser 904nm wavelength have been used to treat the peyronie's disease; CO2 and KTP-532 lasers have been used to treat premalignant and malignant squamous cell lesions of the penis; Nd:YAG, C02, Argon and KTP wavelengths have been used to treat ureteral stricture, ureteral stricture induced chordee; epilation of hair-bearing ureteral grafts; Ablation of posterior ureteral valves, ureteral tumors, ureteral caruncles, and ureteral condylomata accuminata have all been treated with good results. Ho:YAG laser transureteral incision of the prostate (TUIP) facilitates a bloodless TUIP, thus avoiding Catheterization. Laser prostatectomy with a TURPETTE: Nd:YAG laser was used to ablation of the prostate larger than 40g after basing combined with a limited TURP to facilitate the urinary flow recurring the swelling and shortening the duration of necrotic sloughs .Compare TURP with contact laser, interstitial laser finds TULIP in conclusion that TURP is still the gold standard in the treatment of BPH. The results of TULIP, contact laser and interstitial laser are about the same, but the time internals with in the patients become free of symptoms, however, vary widely. Holmium laser resection of the prostate: the technique of HOLRP produces a cavity identical in appearance to: Transureteral resection of the prostate. The-short-term results are excellent but longer-term follow-up is necessary. Nd:YAG laser coagulation prostatectomy: 3 years of experience with 227 patients. Complications included prostatitis in 2.6% of patients, ureteral stricture in 1 .8%, bladder neck stricture in .4.4%, and: reoperation for residual prostate tissue in 5.3%. Four hundred and eleven patients underwent HO:YAG laser resection of the prostate (HOLRP). Transureteral resection of the prostate using Ho:YAG laser produces early results equivalent to or better than those usually associated with electrosurgical TURP with a shorter hospital stay and a lower rate of complications.