Detection of carbon-fluorine bonds in organofluorine compounds by Raman spectroscopy using a copper-vapor laser

Clay M. Sharts; Vladimir S. Gorelik; A. M. Agoltsov; Ludmila I. Zlobina; Olga N. Sharts

doi:10.1117/12.341046

26 February 1999 Detection of carbon-fluorine bonds in organofluorine compounds by Raman spectroscopy using a copper-vapor laser

Clay M. Sharts, Vladimir S. Gorelik, A. M. Agoltsov, Ludmila I. Zlobina, Olga N. Sharts

Author Affiliations +

Proceedings Volume 3537, Electro-Optic, Integrated Optic, and Electronic Technologies for Online Chemical Process Monitoring; (1999) https://doi.org/10.1117/12.341046
Event: Photonics East (ISAM, VVDC, IEMB), 1998, Boston, MA, United States

Abstract

The Raman spectra of fluoro-organic compounds show specific emission bands for carbon-fluorine bonds in the range 500- 800 wave numbers (cm^-1)). With very limited exceptions, biological materials do not contain carbon- fluorine bonds. Fluoro-organic compounds introduced into biological samples can be detected by a Raman emission signal. Normal mode C-F bond bands are observed: (1) at 710- 785 cm ^-1 for trifluoromethyl groups; (2) at 530-610 cm ^-1 for aromatic organofluorine bonds; (3) a range centered at 690 cm ^-1 for difluoromethylene groups. Specific examples of normal mode C-F bond emissions for organofluorine compounds containing trifluoromethyl groups are: 1-bromoperfluorooctane, 726 cm ^-1; perfluorodecanoic acid, 730 cm ^-1; triperfluoropropylamine, 750 cm ^-1; 1,3,5-tris- (trifluoromethyl)-benzene, 730 cm ^-1; Fluoxetine (Prozac) commercial powdered pill at 782 cm ^-1. Compounds containing aromatic C-F bonds are: hexafluorobenzene, 569 cm ^MIN1; pentafluoropyridine, 589 cm ^-1. Difluoromethylene groups: perfluorodecalin, 692 cm^-1; perfluorocyclohexane, 691 cm ^-1. Raman spectra were observed with a standard single monochromator. The 510.8 nm light source was a copper-vapor laser operated at 3-10 watts with 10-12 nanosecond pulses at 10 kHz repetition rate. Detection was made with a time-gated photomultiplier tube. Resonance Raman spectra were also observed at 255.4 nm, using a frequency doubling crystal. Observed spectra were free of fluorescence with very sharp strong C-F lines.

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Clay M. Sharts, Vladimir S. Gorelik, A. M. Agoltsov, Ludmila I. Zlobina, and Olga N. Sharts "Detection of carbon-fluorine bonds in organofluorine compounds by Raman spectroscopy using a copper-vapor laser", Proc. SPIE 3537, Electro-Optic, Integrated Optic, and Electronic Technologies for Online Chemical Process Monitoring, (26 February 1999); https://doi.org/10.1117/12.341046

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