Solution-based analysis of multiple analytes by a sensor array: toward the development of an electronic tongue

Steven M. Savoy; John J. Lavigne; J. Seung-Jin Yoo; John Wright; Marc Rodriguez; Adrian Goodey; Bridget McDoniel; John Thomas McDevitt; Eric V. Anslyn; Jason B. Shear; Andrew D. Ellington; Dean P. Neikirk

doi:10.1117/12.333750

18 December 1998 Solution-based analysis of multiple analytes by a sensor array: toward the development of an electronic tongue

Steven M. Savoy, John J. Lavigne, J. Seung-Jin Yoo, John Wright, Marc Rodriguez, Adrian Goodey, Bridget McDoniel, John Thomas McDevitt, Eric V. Anslyn, Jason B. Shear, Andrew D. Ellington, Dean P. Neikirk

Author Affiliations +

Proceedings Volume 3539, Chemical Microsensors and Applications; (1998) https://doi.org/10.1117/12.333750
Event: Photonics East (ISAM, VVDC, IEMB), 1998, Boston, MA, United States

Abstract

A micromachined sensor array has been developed for the rapid characterization of multi-component mixtures in aqueous media. The sensor functions in a manner analogous to that of the mammalian tongue, using an array composed of individually immobilized polystyrene-polyethylene glycol composite microspheres selectively arranged in micromachined etch cavities localized o n silicon wafers. Sensing occurs via colorimetric or fluorometric changes to indicator molecules that are covalently bound to amine termination sites on the polymeric microspheres. The hybrid micromachined structure has been interfaced directly to a charged-coupled-device that is used for the simultaneous acquisition of the optical data from the individually addressable `taste bud' elements. With the miniature sensor array, acquisition of data streams composed of red, green, and blue color patterns distinctive for the analytes in the solution are rapidly acquired. The unique combination of carefully chosen reporter molecules with water permeable microspheres allows for the simultaneous detection and quantification of a variety of analytes. The fabrication of the sensor structures and the initial colorimetric and fluorescent responses for pH, Ca⁺², Ce⁺³, and sugar are reported. Interface to microfluidic components should also be possible, producing a complete sampling/sensing system.

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Steven M. Savoy, John J. Lavigne, J. Seung-Jin Yoo, John Wright, Marc Rodriguez, Adrian Goodey, Bridget McDoniel, John Thomas McDevitt, Eric V. Anslyn, Jason B. Shear, Andrew D. Ellington, and Dean P. Neikirk "Solution-based analysis of multiple analytes by a sensor array: toward the development of an electronic tongue", Proc. SPIE 3539, Chemical Microsensors and Applications, (18 December 1998); https://doi.org/10.1117/12.333750

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