7 August 1998 Initiation of apoptosis by photosensitization with hypocrellin A and the repression of Vitamin E
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Abstract
PDT-induced HeLa cells apoptosis was evidenced by morphological changes, DNA fragmentation and decrease of mitochondria dehydrogenase activity. Apoptosis was associated with the formation of IP3 of photosensitized cells and rapid release of Ca2+ from intracellular pools. Vitamin E, which was added before irradiation, could significantly protect cells against cell death, indicating that reactive oxygen species (ROS) play an important role in apoptotic cell death.
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En-Hua Cao, En-Hua Cao, Jian Zhang, Jian Zhang, Jingfu Li, Jingfu Li, } "Initiation of apoptosis by photosensitization with hypocrellin A and the repression of Vitamin E", Proc. SPIE 3548, Biomedical Optics and Lasers: Diagnostics and Treatment, (7 August 1998); doi: 10.1117/12.317884; https://doi.org/10.1117/12.317884
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