7 August 1998 Real-time functional near-infrared imager
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A real time functional Near-InfraRed Imager (fNIRI) was presented in this paper. We developed a continuous wave (cw) light imaging probe which includes 9 light sources and 4 pairs detectors (each pair has one 850 nm filtered detector and one 760 nm filtered detector). There are 16 measurement sections and total detection area is 9 cm X 4 cm. The detector- source uses 2.5 cm spacing. The light sources are controlled by a computer and the signals from the detectors are converted and processed in real time by the computer. The user-friendly software was programmed with Visual C++ language. Relative changes of oxy-Hb, Hb, and total blood concentration in 16 channels and the corresponding images combined by 16 channels could be displayed in real time on computer. With this cw imaging probe, we have measured motor function in motor cortex area, visual function in occipital area, and cognitive activity in frontal forehead area of the human brain when the subjects are stimulated by moving fingers, viewing a flashing light and doing an analogy test, respectively. The experimental results show that the cw imaging probe can be used for functional images of brain activity, based upon changes of oxygenation and blood volume due to the stimulus.
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Qingming Luo, Qingming Luo, Shaoqun Zeng, Shaoqun Zeng, Britton Chance, Britton Chance, Shoko Nioka, Shoko Nioka, } "Real-time functional near-infrared imager", Proc. SPIE 3548, Biomedical Optics and Lasers: Diagnostics and Treatment, (7 August 1998); doi: 10.1117/12.317851; https://doi.org/10.1117/12.317851

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