3 February 1999 Interaction between a photosensitizer, chemotherapeutic drug, and HSA: implications for photodynamic therapy
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Photodynamic therpay (PDT) used in combination with chemotherapy leads to enhanced efficiency of the treatment. Steady state spectroscopic studies were performed in order to investigate interaction process between photosensitizer Photohem (PH) and chemotherapeutic drug Adriamycin (ADM). Results obtained in aqueous solutions revealed that ADM disrupts equilibrium aggregates of PH and forms complexes with PH. Changes induced by the complexation with ADM in the absorbance of PH in the red spectral region are insignificant, and the amount of the absorbed light quanta at the primary stage of photosensitization in the case of the combined treatment should be very close to that when only PDT is applied. The increased efficiency of PDT in combination with ADM should probably be related to the changes in photophysical and photochemical properties of photosensitizer and this can lead to modified photosensitizing activity. The observed changes in the phototransformations of photosensitizer conditioned by the complexation with antitumor drug may influence sensitization process during PDT and therefore should be taken into account in the estimation of optimal photodynamic doses.
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Giedre Streckyte, Giedre Streckyte, Saulius Bagdonas, Saulius Bagdonas, Ricardas Rotomskis, Ricardas Rotomskis, } "Interaction between a photosensitizer, chemotherapeutic drug, and HSA: implications for photodynamic therapy", Proc. SPIE 3563, Photochemotherapy of Cancer and Other Diseases, (3 February 1999); doi: 10.1117/12.339129; https://doi.org/10.1117/12.339129

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