Translator Disclaimer
3 February 1999 Type III photosensitization: attempt for quantification and a way toward new sensitizers
Author Affiliations +
Abstract
Earlier results studying the effect of excited triplet photosensitizer on the zymosan-stimulated and luminol- dependent chemiluminescence of macrophages have been quantitatively re-evaluated and rate constant data indicate that the effect is due to triplet-doublet interactions between sensitizer and free radicals generated. Such interactions, named Type III mechanism, compete with Type I and Type II mechanisms depending on the experimental environment. This suggestion resulted in the synthesis of new sensitizers being the first members of the Antioxidant Carrier Sensitizer (ACS) group of molecules. According to preliminary experiments the PDT treatment of tumor bearing mice seems promising with two of such compounds which demonstrate an inhibitory effect in chemical systems already in their ground state.
© (1999) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Tamas Kriska, Judit Jakus, Agnes Keszler, Rozalia Vanyur, Andras Nemeth, and Dezso Gal "Type III photosensitization: attempt for quantification and a way toward new sensitizers", Proc. SPIE 3563, Photochemotherapy of Cancer and Other Diseases, (3 February 1999); https://doi.org/10.1117/12.339133
PROCEEDINGS
7 PAGES


SHARE
Advertisement
Advertisement
Back to Top