4 February 1999 Interest of ICG blood clearance monitoring for reproducible 810-nm diode laser coagulation of blood vessels
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Abstract
Purpose: To evaluate a method of control of diode laser fluence leading to a reproducible ICG-enhanced selective photocoagulation of blood vessels. This method would use the chromophore clearance, i.e. ICG blood concentration decay to adapt the laser fluence. Materials and Methods: A skin flap window was used on hamsters. After a 15 mg/kg ICG solution injection, photocoagulation of vessels were performed. Results: Selective photocoagulation of blood vessels was obtained only during the first 10 minutes. The fluence required to obtain a selective photocoagulation of vessels (F) was modelized using a one compartment phamacokinetic equation: F equals Of(1-e-t/(tau )). The best fit was obtained for a time constant (tau) equals 4.8 min and Of equals 300 J/cm2 (correlation coefficient r2 equals 0.996). During the first 10 minutes, the fluence required for selective photocoagulation of vessels was increased by a factor 4.5. Conclusion: Fluence required for a selective photocoagulation of vessels was correlated to ICG blood concentration decay. The time constant was equivalent to ICG half-life time in human blood. These results demonstrate that diode laser ICG-enhanced photocoagulation can be controlled by monitoring the ICG blood clearance.
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Thomas Desmettre, Thomas Desmettre, Sylvie Soulie-Begu, Sylvie Soulie-Begu, Jean-Marie Devoisselle, Jean-Marie Devoisselle, Serge R. Mordon, Serge R. Mordon, } "Interest of ICG blood clearance monitoring for reproducible 810-nm diode laser coagulation of blood vessels", Proc. SPIE 3564, Medical Applications of Lasers in Dermatology, Cardiology, Ophthalmology, and Dentistry II, (4 February 1999); doi: 10.1117/12.339168; https://doi.org/10.1117/12.339168
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