Testing near-infrared spectrophotometry using a liquid neonatal head phantom

Martin Wolf; Oskar Baenziger; Matthias Keel; Vera Dietz M.D.; Kurt von Siebenthal M.D.; Hans Ulrich Bucher M.D.

doi:10.1117/12.334354

30 December 1998 Testing near-infrared spectrophotometry using a liquid neonatal head phantom

Martin Wolf, Oskar Baenziger, Matthias Keel, Vera Dietz M.D., Kurt von Siebenthal M.D., Hans Ulrich Bucher M.D.

Proceedings Volume 3566, Photon Propagation in Tissues IV; (1998) https://doi.org/10.1117/12.334354
Event: BiOS Europe '98, 1998, Stockholm, Sweden

Abstract

We constructed a liquid phantom, which mimics the neonatal head for testing near infrared spectrophotometry instruments. It consists of a spherical, 3.5 mm thick layer of silicone rubber simulating skin and bone and acts as container for a liquid solution with Intralipid^TM, 60 micrometers ol/l haemoglobin and yeast. The Intralipid^TM concentration was varied to test the influence of scattering on haemoglobin concentrations and tissue oxygenation determined by the Critikon 2020. The solution was oxygenated using pure oxygen and then deoxygenated by the yeast. For the instruments algorithm, we found with increasing scattering (0.5%, 1%, 1.5% and 2% Intralipid^TM concentration) an increasing offset added to the oxy- (56.7, 90.8, 112.5, 145.2 micrometers ol/l respectively) and deoxyhaemoglobin (25.4, 44.3, 58.5, 65.9 micrometers ol/l) concentration causing a decreasing range (41.3, 31.3, 25.0, 22.2%) of the tissue oxygen saturation reading. However, concentration changes were quantified correctly independently of the scattering level. For an other algorithm based on the analytical solution the offsets were smaller: oxyhaemoglobin 12.2, 34.0, 53.2, 88.8 micrometers ol/l and deoxyhaemoglobin 1.6, 11.2, 22.2, 28.1 micrometers ol/l. The range of the tissue oxygen saturation reading was higher: 71.3, 55.5, 45.7, 39.4%. However, concentration changes were not quantified correctly and depended on scattering. This study demonstrates the need to develop algorithms, which take into consideration the anatomical structures.

Citation Download Citation

Martin Wolf, Oskar Baenziger, Matthias Keel, Vera Dietz M.D., Kurt von Siebenthal M.D., and Hans Ulrich Bucher M.D. "Testing near-infrared spectrophotometry using a liquid neonatal head phantom", Proc. SPIE 3566, Photon Propagation in Tissues IV, (30 December 1998); https://doi.org/10.1117/12.334354

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