12 February 1999 Early diagnosis of gastric cancer with laser-induced fluorescence
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Abstract
Optical biopsy of stomach mucosa was performed afterwards oral administration of encapsulated hyperflav (single dose was chosen to provide 0.1 - 0.15 mg/kg b.w.) A sufficient fluorescence contrast of suspicions versus normal tissue was obtained after incubation time from 4 to 10 hours. Fluorescence was induced by He - Cd laser coupled to fiber optic probe inserted into a biopsy channel of the endoscope. Fluorescent spectra were recorded in the range from 500 nm up to 700 nm with 2 nm resolution. We took two groups of patients with benign and malignant ulcer of the stomach and erosive gastritis. The first group consisted of 59 patients (male/female 36/23) was carried out with optical biopsy of stomach mucosa. The second group consisted of 60 patients (male/female 39/21) was carried out by routine method: gastroscopy and biopsy from 5 - 7 places of macroscopically changed mucosa.
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Alexander Y. Joffe, Alexander Y. Joffe, Valeriy F. Sayenko, Valeriy F. Sayenko, Nikolay A. Denisov, Nikolay A. Denisov, Sergiy M. Dets, Sergiy M. Dets, Alexander N. Buryi, Alexander N. Buryi, } "Early diagnosis of gastric cancer with laser-induced fluorescence", Proc. SPIE 3567, Optical and Imaging Techniques for Biomonitoring IV, (12 February 1999); doi: 10.1117/12.339186; https://doi.org/10.1117/12.339186
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