19 January 1999 Fluorescence diagnosis of colon cancer using two novel Rhodamine B derivatives
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Abstract
Fluorescence imaging is a promising technique for the early detection of neoplastic changes in the human body. Investigation of the microscopic origin of tissue fluorescence can provide important information about the histology of tissue. In this study we report the synthesis and use of two novel Rhodamine B derivatives in an efficient microscopic technique for colon cancer diagnosis. Another important objective is the examination of the morphological structures on which the fluorescence analogs bind and the correlation of the fluorescence images with their underlying microstructural origin. Rh B-Leucine amide and Rh B-phenyl boronic acid distinguish clearly healthy from neoplastic colon tissue sections. Both derivatives accumulate mainly in the of neoplastic crypts. This finding can be exploited for colon cancer diagnosis using fluorescence microscopy as well as for a fluorescence-based optical biopsy method.
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Vassilis Atlamazoglou, Vassilis Atlamazoglou, Dido M. Yova, Dido M. Yova, Nikolaos Kavantzas, Nikolaos Kavantzas, Spyros Loukas, Spyros Loukas, } "Fluorescence diagnosis of colon cancer using two novel Rhodamine B derivatives", Proc. SPIE 3568, Optical Biopsies and Microscopic Techniques III, (19 January 1999); doi: 10.1117/12.336828; https://doi.org/10.1117/12.336828
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