29 December 1998 Influence of low-power laser radiation on lung tumor induction in mice
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Abstract
In experiments on 153 non-inbred white female mice lung tumors were induced by subcutaneous injection of urethan (0.5 mg/g) once a week (4 injections as a whole). Mice of the first group were given urethan only. Animals of the second group underwent transcutaneous He-Ne laser irradiation immediately before each urethan injection. Mice of the third group underwent laser irradiation after cessation of 4-week course of urethan. In 2 months after beginning of the experiments, lungs were investigated by light microscopy. It was stated that in animals of the 1st group lung adenomas appeared in 59% of cases. Average amount of tumors per mouse comprised 1.17. In the 2nd group lung tumors were in 82% of animals (p < 0.05). Average amount of tumors per mouse was 1.68. In 2 cases small-cellular lymphocyte-like lung cancer with multicentric growth appeared. Hyperplasia of lymphoid tissue was less in mice with growing tumors. In the animals of the 3d group laser adenomas appeared in 59% of cases. Average amount of tumors per mouse comprised 1.2. It is concluded that He-Ne laser irradiation of animals before injection of chemical carcinogen plays a promising role in the development of murine lung tumors. Laser irradiation after cessation of carcinogen course has no effect on tumor growth.
© (1998) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Gregory E. Brill, Gregory E. Brill, Arkady V. Arkchangelsky, Arkady V. Arkchangelsky, Nadezda P. Panina, Nadezda P. Panina, Galina N. Maslyakova, Galina N. Maslyakova, Elena G. Kulikova, Elena G. Kulikova, Olga V. Proshina, Olga V. Proshina, Alexander G. Brill, Alexander G. Brill, } "Influence of low-power laser radiation on lung tumor induction in mice", Proc. SPIE 3569, Effects of Low-Power Light on Biological Systems IV, (29 December 1998); doi: 10.1117/12.334389; https://doi.org/10.1117/12.334389
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