29 December 1998 Single skin exposure to visible polarized light induces rapid modification of entire circulating blood: II. Appearance of soluble factors restoring proliferation and chromosome structure in X-damag
Author Affiliations +
Abstract
Exposure of a small skin area (400 cm2) of volunteers to visible incoherent polarized (VIP) light (400 - 2000 nm) in therapeutic doses is accompanied by rapid appearance in the circulating blood of soluble factors able to restore proliferation of X-ray-damaged autologous lymphocytes and to decrease frequency of chromosome breaks. The appearance of a such activity in blood can also be induced without skin irradiation, by in vitro modeling of mixing in the circulation of a small amount of transcutaneously VIP- irradiated blood with the intact blood (one volume of the directly VIP-irradiated blood was added to 10 volumes of the intact blood). Hence, the blood (not the skin) is a major source of the active factors. The data obtained indicate a possibility of release of them from photomodified platelets; moreover, the activity restoring chromosome structure in X- damaged cells has been found in the platelet-derived growth factor and epidermal growth factor (which are known to be associated with platelets) when they were added to physiological concentrations to the culture medium. We assume that activation of cell proliferation based on the effective repair of DNA damaged in situ by endogenous and exogenous factors could be one of the mechanisms of photostimulation of wound healing.
© (1998) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Kira A. Samoilova, Kira A. Samoilova, O. I. Zubanova, O. I. Zubanova, S. A. Snopov, S. A. Snopov, N. A. Mukhuradze, N. A. Mukhuradze, V. M. Mikhelson, V. M. Mikhelson, } "Single skin exposure to visible polarized light induces rapid modification of entire circulating blood: II. Appearance of soluble factors restoring proliferation and chromosome structure in X-damag", Proc. SPIE 3569, Effects of Low-Power Light on Biological Systems IV, (29 December 1998); doi: 10.1117/12.334388; https://doi.org/10.1117/12.334388
PROCEEDINGS
8 PAGES


SHARE
Back to Top