28 December 1982 Laser Fluorescence-Absorption Measuring Device For In-Situ Organ Metabolism Investigation
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Abstract
We have developped a device which includes two laser sources (nitrogen laser and dye laser), an optical system, an optical fiber able to transmit ultra-violet, visible and infrared light, photoreceivers and an analog circuit feeding a microcomputer, in order to perform in situ and on line study of NADH/NAD ratio by fluorimetry. The technical description of the device has already been exposed in the SPIE'S Technical Symposium East'81, held in April 81 in Washington DC. We intend now to present the scientific grounds of the method, the technical improvements concerning the propagation of light from the sources to the living tissue as well as from and to the receivers (special processing of the extremities of the optical fiber) and the results of the experiments carried out with several models. Additional information on the non-occurence of the photo-optical artifact and on the considered applications (heart surgery for instance) will be provided.
© (1982) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
G. Renault, E. Raynal, M. Sinet, M. Muffat-Joly, J. P. Berthier, B. Godard, J. Cornillault, "Laser Fluorescence-Absorption Measuring Device For In-Situ Organ Metabolism Investigation", Proc. SPIE 0357, Lasers in Medicine and Surgery, (28 December 1982); doi: 10.1117/12.976075; https://doi.org/10.1117/12.976075
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