15 January 1999 Noninvasive detection of glucose using Raman spectroscopy
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Abstract
We have investigated the possibilities of applying Raman spectroscopy for the in-vivo determination of blood glucose levels. To this end we measured Raman spectra of glucose dissolved in pure water and in the presence of other analytes such as glycogen and proteins. Secondly, we determined the fluorescence of blood serum for different excitation wavelengths. Since all measurements were done in an absolute way, we were able to predict if the Raman signal level of glucose was high enough to permit the in-vivo determination of the physiological glucose levels in blood.
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Johannes Sake Kanger, Frits F. M. de Mul, Cees Otto, "Noninvasive detection of glucose using Raman spectroscopy", Proc. SPIE 3570, Biomedical Sensors, Fibers, and Optical Delivery Systems, (15 January 1999); doi: 10.1117/12.336922; https://doi.org/10.1117/12.336922
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