Monitoring of corneal allograft rejection using laser flare meter

Tomasz Zarnowski; Dariusz Haszcz; Ewa Rakowska; Zbigniew Zagorski

doi:10.1117/12.328309

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22 October 1998 Monitoring of corneal allograft rejection using laser flare meter

Tomasz Zarnowski; Dariusz Haszcz; Ewa Rakowska; Zbigniew Zagorski

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Proceedings Volume 3579, Ophthalmic Measurements and Optometry; (1998) https://doi.org/10.1117/12.328309
Event: Ophthalmic Measurements and Optometry, 1997, Kazimierz Dolny, Poland

Abstract

The purpose of this study was to quantify noninvasively, with the use of laser-flare meter the alterations of the blood-aqueous barrier following penetrating keratoplasty. This could diagnose objectively disruption of this barrier in eyes with early allograft rejection, possible even before manifestation of the clinical signs and would help to monitor the efficacy of the treatment. We used the laser flare-meter (Kowa FM-500) to investigate alteration of the blood-aqueous barrier following uncomplicated penetrating keratoplasty (PK) and in corneal allograft rejection. Examination was performed in 50 eyes of 48 patients after uncomplicated PK (7 days to 12 months after PK), in 20 normal control eyes and in 8 patients with acute allograft rejection. Flare values after uncomplicated keratoplasty slowly decreased in time reaching nearly control values 6 - 12 months postoperatively. They were considerably higher for acute allograft rejection compared to eyes following uncomplicated PK and normal control group. Actually, they tended to diminish gradually after systemic and topical administration of steroids and/or immunosuppressants. Application of laser tyndalometry has been proven to be highly useful in the follow up of patients after perforating keratoplasty-especially high risk grafts, it helps to detect objectively early allograft rejection and is beneficial in monitoring the effectiveness of the treatment.

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Tomasz Zarnowski, Dariusz Haszcz, Ewa Rakowska, and Zbigniew Zagorski "Monitoring of corneal allograft rejection using laser flare meter", Proc. SPIE 3579, Ophthalmic Measurements and Optometry, (22 October 1998); https://doi.org/10.1117/12.328309

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