CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 3590 > Article
Paper
22 June 1999 Effects of transmyocardial laser revascularization using a prototype pulsed CO2 laser on contractility and perfusion of chronically ischemic myocardium in a porcine model
Yasmin Wadia M.D., Ali Khaki, Michio Kajitani M.D., Yoshiki Mori M.D., Timothy Irvine M.D., David Sahn M.D., Michael J. Yessik, Deborah T. Bahlman R.N., Anthony Furnary M.D., Kenton W. Gregory M.D.
Author Affiliations +
Proceedings Volume 3590, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX; (1999) https://doi.org/10.1117/12.350975
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States
Abstract
The purpose of this study was to test a new prototype pulsed CO2 laser to be used for transmyocardial laser revascularization (TMR). We want to determine whether it can reduce thermal damage and mitigate induced ischemia with improvement in contractile reserve of the heart as evidenced by contrast echocardiography at rest and under dobutamine stress. TMR is an emerging surgical strategy for treatment of myocardial ischemia not amenable to conventional percutaneous or surgical revascularization. Eleven pigs underwent amaroid occulder placement on the origin of the circumflex coronary artery. Six weeks laser occlusion of the circumflex coronary artery was documented. TMR was then done on ten pigs using a prototype pulsed CO2 laser that delivered 8-12 joules energy in 1.5ms with a spot sizes of 1mm. Six weeks after TMR the pigs were restudied and sacrificed. The animals developed significant ischemia after six weeks of ameroid occlusion, at rest (p=0.01) and at peak stress (p=0.004). Wall motion for the ischemic segments improved significantly six weeks after TMR at peak stress (p=0.02). TMR results in an improvement in wall motion in our model of chromic ischemia and improves WMSI significantly during induced stress than at rest.
© (1999) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Yasmin Wadia M.D., Ali Khaki, Michio Kajitani M.D., Yoshiki Mori M.D., Timothy Irvine M.D., David Sahn M.D., Michael J. Yessik, Deborah T. Bahlman R.N., Anthony Furnary M.D., and Kenton W. Gregory M.D. "Effects of transmyocardial laser revascularization using a prototype pulsed CO2 laser on contractility and perfusion of chronically ischemic myocardium in a porcine model", Proc. SPIE 3590, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX, (22 June 1999); https://doi.org/10.1117/12.350975
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 12 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Echocardiography
Carbon dioxide lasers
Arteries
Ischemia
Pulsed laser operation
Angiography
Prototyping
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top