Acute optic nerve sheath fenestration with the free-electron laser

Jin-Hui Shen; Vivien A. Casagrande; Karen Margaret Joos M.D.; Debra J. Shetlar; Richard D. Robinson; William S. Head; Julia A. Mavity-Hudson; Amy H. Nunnally

doi:10.1117/12.350585

18 June 1999 Acute optic nerve sheath fenestration with the free-electron laser

Jin-Hui Shen, Vivien A. Casagrande, Karen Margaret Joos M.D., Debra J. Shetlar, Richard D. Robinson, William S. Head, Julia A. Mavity-Hudson, Amy H. Nunnally

Author Affiliations +

Proceedings Volume 3591, Ophthalmic Technologies IX; (1999) https://doi.org/10.1117/12.350585
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

Purpose: To determine if the free electron laser (FEL) energy can be delivered to a small space to perform optic nerve sheath fenestration with minimal acute nerve damage. Methods: A 530 mm hollow waveguide probe was designed. Optic nerve sheath fenestration (1.0 mm diameter) was performed in 8 rabbits using either the FEL (4 eyes, 6.45mm, 10 Hz, 2 mJ) or a knife (4 eyes). Within 2 hours following surgery, the animals were perfused with aldehyde fixative. The integrity of the optic nerve and glial response at the site of fenestration were evaluated on tissue selections with H&E, and antibodies to S100β or GFAP. Results: Surgery using the FEL probe was found to be technically superior to the knife. The glial reaction was limited to a zone adjacent to the fenestration and was similar in both the FEL and knife incisions. Conclusions: The FEL appears capable of efficiently performing an optic nerve sheath fenestration in a small space with minimal acute damage. Both the FEL and knife incisions result in a rapid glial response at the site of fenestration even when optic nerve integrity is not compromised.

Citation Download Citation

Jin-Hui Shen, Vivien A. Casagrande, Karen Margaret Joos M.D., Debra J. Shetlar, Richard D. Robinson, William S. Head, Julia A. Mavity-Hudson, and Amy H. Nunnally "Acute optic nerve sheath fenestration with the free-electron laser", Proc. SPIE 3591, Ophthalmic Technologies IX, (18 June 1999); https://doi.org/10.1117/12.350585

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available