18 June 1999 Acute optic nerve sheath fenestration with the free-electron laser
Author Affiliations +
Proceedings Volume 3591, Ophthalmic Technologies IX; (1999) https://doi.org/10.1117/12.350585
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States
Purpose: To determine if the free electron laser (FEL) energy can be delivered to a small space to perform optic nerve sheath fenestration with minimal acute nerve damage. Methods: A 530 mm hollow waveguide probe was designed. Optic nerve sheath fenestration (1.0 mm diameter) was performed in 8 rabbits using either the FEL (4 eyes, 6.45mm, 10 Hz, 2 mJ) or a knife (4 eyes). Within 2 hours following surgery, the animals were perfused with aldehyde fixative. The integrity of the optic nerve and glial response at the site of fenestration were evaluated on tissue selections with H&E, and antibodies to S100β or GFAP. Results: Surgery using the FEL probe was found to be technically superior to the knife. The glial reaction was limited to a zone adjacent to the fenestration and was similar in both the FEL and knife incisions. Conclusions: The FEL appears capable of efficiently performing an optic nerve sheath fenestration in a small space with minimal acute damage. Both the FEL and knife incisions result in a rapid glial response at the site of fenestration even when optic nerve integrity is not compromised.
© (1999) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Jin-Hui Shen, Vivien A. Casagrande, Karen Margaret Joos, Debra J. Shetlar, Richard D. Robinson, William S. Head, Julia A. Mavity-Hudson, Amy H. Nunnally, "Acute optic nerve sheath fenestration with the free-electron laser", Proc. SPIE 3591, Ophthalmic Technologies IX, (18 June 1999); doi: 10.1117/12.350585; https://doi.org/10.1117/12.350585

Back to Top