19 May 1999 Real time fiber optic detection of lethal thermal injury in vivo
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Proceedings Volume 3594, Thermal Treatment of Tissue with Image Guidance; (1999) https://doi.org/10.1117/12.348728
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States
Abstract
Accurate detection of the full extent of lethal thermal injury during and immediately after heating in interstitial thermal therapy is necessary to control the treatment volume while conserving surrounding tissues. A red zone of thermal injury forms in most tissues within thirty seconds as a result of physiologic response to heat in vivo. The red zone is formed by accumulation of blood due to hemostasis, hemorrhage and hyperhemia. The distinct outer boundary of this zone has been found to correspond to the outer boundary of tissue necrosis in rat livers examined 3 days after thermal coagulation. We have developed a minimally invasive fiberoptic probe that can detect this boundary using changes in white light absorption spectra of hemoglobin compared to native tissue. Decreased reflected light intensity marks the development of the outer boundary of the red thermal damage zone that is a hallmark of the full extent of lethal thermal damage.
© (1999) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Sharon L. Thomsen, Jon A. Schwartz, Edward L. Sinofsky, "Real time fiber optic detection of lethal thermal injury in vivo", Proc. SPIE 3594, Thermal Treatment of Tissue with Image Guidance, (19 May 1999); doi: 10.1117/12.348728; https://doi.org/10.1117/12.348728
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