Investigation of Barrett's esophagus by ultraviolet and visible fluorescence emission and excitation spectroscopy

Alvin Katz; Paul M. Basuk; Howard E. Savage; Mark Chu; Nasser Altorki; Tom Godwin; Steven A. McCormick; Robert R. Alfano

doi:10.1117/12.356835

15 July 1999 Investigation of Barrett's esophagus by ultraviolet and visible fluorescence emission and excitation spectroscopy

Alvin Katz, Paul M. Basuk, Howard E. Savage, Mark Chu, Nasser Altorki, Tom Godwin, Steven A. McCormick, Robert R. Alfano

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Proceedings Volume 3597, Optical Tomography and Spectroscopy of Tissue III; (1999) https://doi.org/10.1117/12.356835
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

In this work, ultraviolet and visible emission and excitation fluorescence spectroscopy was performed on excised human gastrointestinal tissue for the purpose of determining whether fluorescence measurements can be used to detect and monitor patients with BarrettÕs esophagus. Tissue samples were acquired from eleven esophagectomy patients. For each excised esophagus, spectral measurements were taken from multiple locations of normal, malignant and, when present, suspected BarrettÕs tissue. At each site scanned, a biopsy sample was removed for histopathology and the results were correlated with spectral measurements. Differences were observed in the spectra from BarrettÕs, normal, and malignant esophageal tissue. Initial results indicate that these differences in spectra can clearly distinguish normal, BarrettÕs and malignant tissue, and may allow in vivo optical detection of dysplasia in patients with BarrettÕs esophagus during endoscopic examinations.

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Alvin Katz, Paul M. Basuk, Howard E. Savage, Mark Chu, Nasser Altorki, Tom Godwin, Steven A. McCormick, and Robert R. Alfano "Investigation of Barrett's esophagus by ultraviolet and visible fluorescence emission and excitation spectroscopy", Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); https://doi.org/10.1117/12.356835

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KEYWORDS

Cancer

Esophagus

Tissues

Tissue optics

Luminescence

Ultraviolet radiation

Biopsy

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