15 July 1999 Near-infrared spectroscopy and the tilting table protocol: a novel method to study the blood flow and the oxygen consumption in tissues
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Proceedings Volume 3597, Optical Tomography and Spectroscopy of Tissue III; (1999) https://doi.org/10.1117/12.356789
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States
Abstract
We present a novel technique based on tilting the bed where the subject is lying, to non-invasively measure the tissue blood flow (BF) and oxygen consumption (OC) with near-infrared (NIR) spectroscopy. We used a NIR, frequency domain spectrometer to measure the concentrations of oxy-hemoglobin ([HbO2]), deoxy-hemoglobin ([Hb]) and total hemoglobin (THC) in the calf muscle of human subjects. The subject was lying horizontally, and after a baseline acquisition, the bed was tilted by 10 degrees (feet down, head up). This position was kept for 1 min, then the subject was brought back to the horizontal position. This tilting procedure caused variations in the calf [Hb02], [Hb], and THC similar to those observed during a pneumatic-cuff-induced venous occlusion. The increasing rate of THC and [Hb] caused by tilting allowed the calculation of blood flow and oxygen consumption. We found a quantitative agreement between the values of BF (OC) measured with the tilting table and with the venous occlusion protocols. On the 26 subjects examined with the tilting table protocol, we found population average values of BF = 1.51 ml (100ml)-1-min-1 and OC = 6.10 ?mol( 100ml)-1 min-1.
© (1999) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Claudia Casavola, Lelia Adelina Paunescu, Maria-Angela Franceschini, Sergio Fantini, Lew Winter, Jin Kim, Debra Wood, Enrico Gratton, "Near-infrared spectroscopy and the tilting table protocol: a novel method to study the blood flow and the oxygen consumption in tissues", Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); doi: 10.1117/12.356789; https://doi.org/10.1117/12.356789
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