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15 July 1999 Real-time optical imaging and spectroscopy of brain ischemia and hemorrhage
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Proceedings Volume 3597, Optical Tomography and Spectroscopy of Tissue III; (1999)
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States
Perinatal brain injury, a major cause of neurological morbidity in infants, might be prevented or ameliorated if the preceding cerebrovascular disturbances known to cause brain ischemia and hemorrhage could be detected and monitored. We used an ISS tissue oximeter (model 96208, 110 MHz modulated light at two NIR wavelengths) to detect and monitor the development of experimental brain ischemia and hemorrhage by frequency domain optical spectroscopy (8-source/1-detector probe) and CW imaging (16-source/2-detector probe) in nineteen instrumented and ventilated newborn piglets. Our study demonstrates: 1) the sensitivity of the ISS system to detect <0.04 mL of blood at a depth of 1-2 cm; 2) the specificity to distinguish subcortical, subarachnoid, and intraventricular hemorrhage; 3) the possibility of using the optically detected arterial pulse signal to differentiate injured from functional brain regions. In the case of subcortical hemorrhage, we observed that the measured cerebral pa increased linearly with the sectional area of the hematoma rather than with the volume of injected blood. A 1-min movie clip demonstrates the ability of the ISS system to perform the very fast (0.19 s per image) imaging of the developing brain ischemia and hemorrhage.
© (1999) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Miljan R. Stankovic M.D., Dennis M. Hueber, Dev Maulik, Phillip G. Stubblefield, Warren Rosenfeld, Enrico Gratton, Maria-Angela Franceschini, and Sergio Fantini "Real-time optical imaging and spectroscopy of brain ischemia and hemorrhage", Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999);

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