Small-volume tissue spectroscopy using photon-density waves: apparatus and technique

Ilya V. Yaroslavsky; Albert Terenji; Stefan Willmann; Anna N. Yaroslavsky; Harald Busse; Hans-Joachim Schwarzmaier M.D.

doi:10.1117/12.356843

15 July 1999 Small-volume tissue spectroscopy using photon-density waves: apparatus and technique

Ilya V. Yaroslavsky, Albert Terenji, Stefan Willmann, Anna N. Yaroslavsky, Harald Busse, Hans-Joachim Schwarzmaier M.D.

Author Affiliations +

Proceedings Volume 3597, Optical Tomography and Spectroscopy of Tissue III; (1999) https://doi.org/10.1117/12.356843
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

Optical reflectance spectroscopy of turbid media is one of promising novel techniques for diagnostics and monitoring of biological tissues. A widely used approach in the realization of this technique is the application of photon-density waves. Until recently, the frequency-domain techniques have been limited to probing relatively large volumes of tissue. Main reason for this limitation was almost exclusive use of the diffusion approximation for the interpretation of the measured data. The diffusion model becomes invalid for source-detector separations less than several transport mean free paths (approximately 5-7 mm for most of the soft tissues in the near-infrared spectral range). We have developed an inverse technique that allows data processing even at small source-detector separations. This technique is based on a frequency-domain-optiinized Monte Carlo algorithm as a light propagation model. A specially designed acceleration scheme affords using the technique as a forward method in an iterative inverse algorithm. In this paper, a description of the technique is given, and results of simulations and preliminary phantom experiments are presented.

Citation Download Citation

Ilya V. Yaroslavsky, Albert Terenji, Stefan Willmann, Anna N. Yaroslavsky, Harald Busse, and Hans-Joachim Schwarzmaier M.D. "Small-volume tissue spectroscopy using photon-density waves: apparatus and technique", Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); https://doi.org/10.1117/12.356843

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