Spectroscopic and time-sliced imaging of human breast tissue

S. K. Gayen; M. E. Zevallos; Bidyut Baran Das; Robert R. Alfano

doi:10.1117/12.356851

15 July 1999 Spectroscopic and time-sliced imaging of human breast tissue

S. K. Gayen, M. E. Zevallos, Bidyut Baran Das, Robert R. Alfano

Proceedings Volume 3597, Optical Tomography and Spectroscopy of Tissue III; (1999) https://doi.org/10.1117/12.356851
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

Two-dimensional transillumination images of in vitro human breast tissue specimens were recorded as a function of the wavelength of near-infrared laser light, as well as, the position of picosecond-duration temporal slices of transmitted light pulse. Spectroscopic imaging arrangement made use of 1225 - 1300 nm light from a chromium-doped forsterite laser for sample illumination, a Fourier space gate and a polarization gate to sort out a fraction of the image-bearing photons, and an InGaAs area camera for recording two-dimensional images. Time-sliced imaging approach used 800-nm, approximately 130-fs duration, 1 kHz repetition-rate pulses from a Ti:sapphire laser system to illuminate the sample, and a gated imaging system that provided a variable-position, ~80 ps-duration electronic gate to record time-sliced two-dimensional images. Excised female breast tissue specimens comprising normal and cancerous, as well as, adipose and fibrous tissues were imaged. Marked enhancement of image contrast between adipose and fibrous tissues in the specimen was observed when the wavelength of imaging light was near-resonant with an absorption band of the human fatty tissue centered on 1203 nm. In time-sliced images, earlier time slices highlighted cancerous tissues, while the later slices accentuated the normal tissues in most of the specimens.

Citation Download Citation

S. K. Gayen, M. E. Zevallos, Bidyut Baran Das, and Robert R. Alfano "Spectroscopic and time-sliced imaging of human breast tissue", Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); https://doi.org/10.1117/12.356851

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KEYWORDS

Tissues

Breast

Imaging spectroscopy

Spectroscopy

Imaging systems

Picosecond phenomena

Absorption

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