Tumor oximetry: a comparison between near-infrared frequency-domain spectroscopy of hemoglobin saturation and 19F MRI of hexafluorobenzene

Katherine L. Worden; Yulin Song; Xin Jiang; Anca Constantinescu; Ralph P. Mason; Hanli Liu

doi:10.1117/12.356786

15 July 1999 Tumor oximetry: a comparison between near-infrared frequency-domain spectroscopy of hemoglobin saturation and ¹⁹F MRI of hexafluorobenzene

Katherine L. Worden, Yulin Song, Xin Jiang, Anca Constantinescu, Ralph P. Mason, Hanli Liu

Author Affiliations +

Proceedings Volume 3597, Optical Tomography and Spectroscopy of Tissue III; (1999) https://doi.org/10.1117/12.356786
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

Studies have shown that hypoxic tumor cells are relatively more resistant to radiotherapy, chemotherapy, and photodynamic therapy. Tumor oximetry, e.g., measurement of oxygen tension (PO2) of tissue and/or blood oxygenation (S02) of the vascular bed, could be valuable for optimizing treatment plans. In this study, we employed a recently developed homodyne system to measure changes in hemoglobin saturation (S02) and concentration in the vascular bed of rat prostate and breast tumors. For comparison, tissue p02 values were measured using 19F MR EPI of hexafluorobenzene, providing a map of regional tumor oxygenation tension. Both S02 and p02 measurements were taken while the inhaled gas was alternated between 33% oxygen, 100% oxygen and carbogen (95% oxygen, 5% C02). The results obtained for both techniques showed significant changes in tumor oxygenation accompanying respiratory challenge, with changes in vascular S02 preceding tissue p02 change. The combined use of these two techniques provides new insight into the dynamics of tumor oxygenation by making available a method of obtaining regional information of the state of the tissue, as well as a non-invasive, real-time method for determining changes in the vascular bed.

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Katherine L. Worden, Yulin Song, Xin Jiang, Anca Constantinescu, Ralph P. Mason, and Hanli Liu "Tumor oximetry: a comparison between near-infrared frequency-domain spectroscopy of hemoglobin saturation and ¹⁹F MRI of hexafluorobenzene", Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); https://doi.org/10.1117/12.356786

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