30 April 1999 Determination of burn depth by polarization-sensitive optical coherence tomography
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Proceedings Volume 3598, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III; (1999); doi: 10.1117/12.347475
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States
Abstract
Burn depth assessment is a key step guiding the treatment plan in patients who have sustained thermal injuries. We have developed a technique, polarization sensitive optical coherence tomography (PS-OCT), to provide the physician with a quantitative estimate of actual burn depth. We generated burns of various depths by contacting rates with a brass rod preheated to 75 degrees for 5, 15, or 30 seconds. PS-OCT imags birefringence in biological tissue, through the depth resolved changes in the polarization state of light propagated and reflected from the sample. Preliminary result are presented that show a correlation between the loss of birefringence due to thermal injury and the actual burn depth determined by histological analysis. PS-OCT is a noninvasive technique which potentially can give physicians the accuracy to formulate the best treatment plan for burn patients.
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Shyam M. Srinivas, Johannes F. de Boer, Boris Hyle Park, Kurosh Keikhanzadeh, Leah Huang, Zhongping Chen, J. Stuart Nelson, "Determination of burn depth by polarization-sensitive optical coherence tomography", Proc. SPIE 3598, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III, (30 April 1999); doi: 10.1117/12.347475; http://dx.doi.org/10.1117/12.347475
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KEYWORDS
Skin

Polarization

Injuries

Birefringence

Tissue optics

Tissues

Biopsy

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