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30 April 1999 Imaging water absorption with OCT
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Proceedings Volume 3598, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III; (1999)
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States
Optical coherence tomography (OCT) systems normally operate in regions of the near-IR spectrum in which absorption losses are small compared to scattering losses. We have been exploring the concept of absorption imaging with OCT using a pair of sources that emit on either side of an edge of a strong absorption band of water. In this report a method is introduced for measurement of differential absorption that is based on Fourier transformation of partially coherent interference signals. In experiments designed to test the feasibility of the method, we measured local water concentrations in tissue phantoms and the hydrated epidermis of living skin using a specially configured interferometer illuminated by LEDs that emit in bands centered on 1310 nm and 1460 nm. The results show that absorption losses can be measured in spite of inherent noise form backscattering variations and speckle, but the need for signal averaging places a lower limit on the sampling volume. New inversion algorithms for true tomographic imaging are under development that take advantage of the multiple projections of a scanned conical beam.
© (1999) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Joseph M. Schmitt, Jianwen Hua, and Jianan Y. Qu "Imaging water absorption with OCT", Proc. SPIE 3598, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III, (30 April 1999);

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