Method and device for noninvasive blood glucose measurement

Airat K. Amerov; Kye Jin Jeon; Yoen-Joo Kim; Gilwon Yoon

doi:10.1117/12.348382

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17 May 1999 Method and device for noninvasive blood glucose measurement

Airat K. Amerov; Kye Jin Jeon; Yoen-Joo Kim; Gilwon Yoon

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Proceedings Volume 3599, Optical Diagnostics of Biological Fluids IV; (1999) https://doi.org/10.1117/12.348382
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

The method and device for non-invasive measurement of blood glucose concentration based on the diffuse reflectance from the transcutaneous layers is proposed. Original normalizing ratio algorithm permitting to separate glucose absorption from absorption of other blood components is suggested. It was shown that the influence of water and some other components such as hemoglobin, albumin, globulin's and cholesterol concentration variations to the estimation of the glucose concentration can be compensated using spectral analysis of the reflection on several specially selected wavelengths and proposed algorithm. Device with optical geometry minimizing the effects of changes in the scattering background of biological tissues was developed. NIR spectral range 800 - 1800 nm was used because of its good transparency for biological tissue and presence of glucose absorption band. We used two kinds of light sources, namely LED array and Xe flash lamp. Tissue phantoms (different glucose concentration (0 - 1000 mg/dl) solutions with polystyrene beads or with milk) were used as samples. Scattering and absorption contribution to the dependence of diffuse reflection on glucose concentration was experimentally verified.

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Airat K. Amerov, Kye Jin Jeon, Yoen-Joo Kim, and Gilwon Yoon "Method and device for noninvasive blood glucose measurement", Proc. SPIE 3599, Optical Diagnostics of Biological Fluids IV, (17 May 1999); https://doi.org/10.1117/12.348382

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