Multipixel frequency-domain imaging of spontaneous canine breast disease using fluorescent contrast agents

Jeffery S. Reynolds; Alan B. Thompson; Tamara L. Troy; Ralf H. Mayer; David J. Waters; Eva Marie Sevick-Muraca

doi:10.1117/12.351035

2 July 1999 Multipixel frequency-domain imaging of spontaneous canine breast disease using fluorescent contrast agents

Jeffery S. Reynolds, Alan B. Thompson, Tamara L. Troy, Ralf H. Mayer, David J. Waters, Eva Marie Sevick-Muraca

Proceedings Volume 3600, Biomedical Imaging: Reporters, Dyes, and Instrumentation; (1999) https://doi.org/10.1117/12.351035
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

In this paper we demonstrate the ability to detect the frequency-domain fluorescent signal from the contrast agent indocyanine green within the mammary chain of dogs with spontaneous mammary tumors. We use a gain-modulated image intensifier to rapidly capture multi-pixel images of the fluorescent modulation amplitude, modulation phase, and average intensity signals. Excitation is provided by a 100 MHz amplitude-modulated, 780 nm laser diode. Time series images of the uptake and clearance of the contrast agent in the diseased tissue are also presented.

Citation Download Citation

Jeffery S. Reynolds, Alan B. Thompson, Tamara L. Troy, Ralf H. Mayer, David J. Waters, and Eva Marie Sevick-Muraca "Multipixel frequency-domain imaging of spontaneous canine breast disease using fluorescent contrast agents", Proc. SPIE 3600, Biomedical Imaging: Reporters, Dyes, and Instrumentation, (2 July 1999); https://doi.org/10.1117/12.351035

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