14 June 1999 Investigations to monitor laser-induced thermotherapy (LITT) of breast tumors with photon density waves (PDW)
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Proceedings Volume 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical; (1999) https://doi.org/10.1117/12.350037
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States
Abstract
An experimental setup will be presented which provides the detection of photon density waves (PDW) in transmission through tissue samples of up to 4 cm thickness. A laser diode (825 nm) which was modulated at frequencies between 40 - 1000 MHz served as light source. Amplitude and phase of the PDW were measured at various positions on tissue phantoms as well as during interstitial laser coagulation of tissue samples (porcine liver) by scanning source and detector. A Nd:YAG laser was used in combination with a scattering applicator to produce thermal lesions. Due to a change of the optical properties the actual size of the coagulated volume could be monitored during the therapy. Several phantom and in vitro experiments have been performed to show that this monitoring technique is capable of visualizing the coagulated region with a clinically relevant precision.
© (1999) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
I. Mesecke-von Rheinbaben, Andre Roggan, Y. Helfman, Uwe Netz, G. Mueller, "Investigations to monitor laser-induced thermotherapy (LITT) of breast tumors with photon density waves (PDW)", Proc. SPIE 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical, (14 June 1999); doi: 10.1117/12.350037; https://doi.org/10.1117/12.350037
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