14 June 1999 Photodynamic processes of cholesteryl oleate accumulated on the arterial wall using IR free electron lasers
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Proceedings Volume 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical; (1999) https://doi.org/10.1117/12.349993
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States
Abstract
The selective removal of cholesterol esters accumulated in the intra-cellular or extra-cellular spaces has clinical significance. In the present work we investigate the removal of cholesterol esters by using a free electron laser (FEL) in an arteriosclerotic region. Thin films of cholesteryl oleate and albumin, and the cross section of a rabbit artery were placed on an inverted microscope stage and the changes caused by the FEL irradiation of 5.75 micrometer and 6.1 micrometer with 1.5 - 3 mW in average were monitored continuously by a CCD camera in real time. FEL irradiation at a wavelength of 5.75 micrometer, which is a stretching vibrational mode of the ester, was able to ablate cholesterol esters without affecting albumin and that it can also remove cholesterol esters from rabbits' arteriosclerotic arterial walls.
© (1999) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Kunio Awazu, Kunio Awazu, Katsuo Aizawa, Katsuo Aizawa, } "Photodynamic processes of cholesteryl oleate accumulated on the arterial wall using IR free electron lasers", Proc. SPIE 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical, (14 June 1999); doi: 10.1117/12.349993; https://doi.org/10.1117/12.349993
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