17 June 1999 Single-virus analysis by correlated optical spectroscopy and atomic force microscopy
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Proceedings Volume 3607, Scanning and Force Microscopies for Biomedical Applications; (1999); doi: 10.1117/12.350617
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States
Abstract
Single adeno- and tobacco mosaic viruses have been studied by correlated fluorescence spectroscopy and tapping-mode atomic force microscopy. The size and shape of spatially isolated, fluorescently tagged viruses are measured on the nanometer scale, and the fluorescent labels in each virus are determined by wavelength-resolved spectroscopy. This work extends ultrasensitive measurement to the single-virus level and is expected to have applications in studying gene therapy vectors and virus-cell interactions.
© (1999) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Warren C. W. Chan, Shuming Nie, "Single-virus analysis by correlated optical spectroscopy and atomic force microscopy", Proc. SPIE 3607, Scanning and Force Microscopies for Biomedical Applications, (17 June 1999); doi: 10.1117/12.350617; https://doi.org/10.1117/12.350617
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KEYWORDS
Atomic force microscopy

Particles

Viruses

Luminescence

Imaging spectroscopy

Optical spheres

Latex

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