Advances in fiber optic Raman instrumentation

Kevin L. Davis; James M. Tedesco; Jeremy M. Shaver

doi:10.1117/12.345396

9 April 1999 Advances in fiber optic Raman instrumentation

Kevin L. Davis, James M. Tedesco, Jeremy M. Shaver

Author Affiliations +

Proceedings Volume 3608, Biomedical Applications of Raman Spectroscopy; (1999) https://doi.org/10.1117/12.345396
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

The analytical potential for routine Raman analyses has promoted the development of class 1 instruments configured for analytical laboratory use. A particular topic of interest regarding these systems for the biomedical and pharmaceutical fields is calibration standardization. Widespread acceptance of Raman spectroscopy in regulated industries requires automated, reliable, traceable instrument calibration. Key dispersive Raman analyzer elements that require calibration include excitation laser wavelength, Raman emission wavelengths, and the spectral response profile of the instrument. In this paper we will detail recent developments in fiber optically coupled Raman instruments. Hardware approaches to calibration issues will be the primary focus of this discussion. Candidate wavelength and intensity calibration references are evaluated. Potential system calibration/qualification protocols are discussed.

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Kevin L. Davis, James M. Tedesco, and Jeremy M. Shaver "Advances in fiber optic Raman instrumentation", Proc. SPIE 3608, Biomedical Applications of Raman Spectroscopy, (9 April 1999); https://doi.org/10.1117/12.345396

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