28 May 1999 Hard x-ray quantitative noninterferometric phase-contrast imaging
Author Affiliations +
Abstract
We report the results of quantitative hard X-ray phase- contrast microscopy and tomography using synchrotron radiation, in-line imaging geometry and a non-interferometric phase retrieval technique based on the Transport of Intensity equation. This quantitative imaging method is fast, simple, robust, does not require sophisticated X-ray optical elements and can potentially provide submicron spatial resolution over a field of view of the order of centimeters. In the present experiment a spatial resolution of approximately 0.8 micron has been achieved in images of a polystyrene sphere using 19.6 keV X-rays. We demonstrate that appropriate processing of phase-contrast images obtained in the in-line geometry can reveal important new information about the internal structure of weakly absorbing organic samples. We present some preliminary results of a phase-contrast tomographic reconstruction with and without phase retrieval in each X-ray projection. We believe that this method of quantitative X-ray phase-contrast imaging will find applications in biology and medicine, particularly for high-contrast imaging of soft tissues.
© (1999) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Timur E. Gureyev, Carsten Raven, Anatoly A. Snigirev, Irina Snigireva, Stephen W. Wilkins, "Hard x-ray quantitative noninterferometric phase-contrast imaging", Proc. SPIE 3659, Medical Imaging 1999: Physics of Medical Imaging, (28 May 1999); doi: 10.1117/12.349510; https://doi.org/10.1117/12.349510
PROCEEDINGS
9 PAGES


SHARE
RELATED CONTENT


Back to Top