28 May 1999 Hard x-ray quantitative noninterferometric phase-contrast imaging
Author Affiliations +
Abstract
We report the results of quantitative hard X-ray phase- contrast microscopy and tomography using synchrotron radiation, in-line imaging geometry and a non-interferometric phase retrieval technique based on the Transport of Intensity equation. This quantitative imaging method is fast, simple, robust, does not require sophisticated X-ray optical elements and can potentially provide submicron spatial resolution over a field of view of the order of centimeters. In the present experiment a spatial resolution of approximately 0.8 micron has been achieved in images of a polystyrene sphere using 19.6 keV X-rays. We demonstrate that appropriate processing of phase-contrast images obtained in the in-line geometry can reveal important new information about the internal structure of weakly absorbing organic samples. We present some preliminary results of a phase-contrast tomographic reconstruction with and without phase retrieval in each X-ray projection. We believe that this method of quantitative X-ray phase-contrast imaging will find applications in biology and medicine, particularly for high-contrast imaging of soft tissues.
© (1999) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Timur E. Gureyev, Timur E. Gureyev, Carsten Raven, Carsten Raven, Anatoly A. Snigirev, Anatoly A. Snigirev, Irina Snigireva, Irina Snigireva, Stephen W. Wilkins, Stephen W. Wilkins, } "Hard x-ray quantitative noninterferometric phase-contrast imaging", Proc. SPIE 3659, Medical Imaging 1999: Physics of Medical Imaging, (28 May 1999); doi: 10.1117/12.349510; https://doi.org/10.1117/12.349510
PROCEEDINGS
9 PAGES


SHARE
RELATED CONTENT


Back to Top