28 May 1999 Hard x-ray quantitative noninterferometric phase-contrast imaging
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We report the results of quantitative hard X-ray phase- contrast microscopy and tomography using synchrotron radiation, in-line imaging geometry and a non-interferometric phase retrieval technique based on the Transport of Intensity equation. This quantitative imaging method is fast, simple, robust, does not require sophisticated X-ray optical elements and can potentially provide submicron spatial resolution over a field of view of the order of centimeters. In the present experiment a spatial resolution of approximately 0.8 micron has been achieved in images of a polystyrene sphere using 19.6 keV X-rays. We demonstrate that appropriate processing of phase-contrast images obtained in the in-line geometry can reveal important new information about the internal structure of weakly absorbing organic samples. We present some preliminary results of a phase-contrast tomographic reconstruction with and without phase retrieval in each X-ray projection. We believe that this method of quantitative X-ray phase-contrast imaging will find applications in biology and medicine, particularly for high-contrast imaging of soft tissues.
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Timur E. Gureyev, Timur E. Gureyev, Carsten Raven, Carsten Raven, Anatoly A. Snigirev, Anatoly A. Snigirev, Irina Snigireva, Irina Snigireva, Stephen W. Wilkins, Stephen W. Wilkins, } "Hard x-ray quantitative noninterferometric phase-contrast imaging", Proc. SPIE 3659, Medical Imaging 1999: Physics of Medical Imaging, (28 May 1999); doi: 10.1117/12.349510; https://doi.org/10.1117/12.349510


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