Functional magnetic resonance imaging of the rat cerebellum during electrical stimulation of the fore- and hindpaw at 7 T

Ronald Peeters; Marleen Verhoye; Bart Vos; Erik De Schutter; Anne-Marie Van der Linden

doi:10.1117/12.349611

20 May 1999 Functional magnetic resonance imaging of the rat cerebellum during electrical stimulation of the fore- and hindpaw at 7 T

Ronald Peeters, Marleen Verhoye, Bart Vos, Erik De Schutter, Anne-Marie Van der Linden

Author Affiliations +

Proceedings Volume 3660, Medical Imaging 1999: Physiology and Function from Multidimensional Images; (1999) https://doi.org/10.1117/12.349611
Event: Medical Imaging '99, 1999, San Diego, CA, United States

Abstract

Blood oxygenation level dependent contrast (BOLD) functional MRI responses at 7T were observed in the cerebellum of alpha- chloralose anesthetized rats in response to innocuous electrical stimulation of a forepaw or hindpaw. The responses were imaged in both coronal and sagittal slices which allowed for a clear delineation and localization of the observed activations. We demonstrate the validity of our fMRI protocol by imaging the responses in somatosensory cortex to the same stimuli and by showing a high level of reproducibility of the cerebellar responses. Widespread bilateral activations were found with mainly a patchy and medio-lateral band organization, more pronounced ipsilaterally. There was no overlap between the cerebellar activations caused by forepaw or hindpaw stimulation. Most remarkable was the overall horizontal organization of these responses: for both stimulation paradigms the patches and bands of activation were roughly positioned in either a cranial or caudal plane running antero-posteriorly through the whole cerebellum. This is the first fMRI study in the cerebellum of the rat. We relate our findings to the known projection patterns found with other techniques and to human fMRI studies. The horizontal organization found wasn't observed before in other studies using other techniques.

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Ronald Peeters, Marleen Verhoye, Bart Vos, Erik De Schutter, and Anne-Marie Van der Linden "Functional magnetic resonance imaging of the rat cerebellum during electrical stimulation of the fore- and hindpaw at 7 T", Proc. SPIE 3660, Medical Imaging 1999: Physiology and Function from Multidimensional Images, (20 May 1999); https://doi.org/10.1117/12.349611

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