20 May 1999 Lateralization effects of image-guided 31P magnetoresonance spectroscopic parameters in the frontal lobe of schizophrenics and healthy controls
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Abstract
Phosphorus-31 magnetic resonance spectroscopy (31P-MRS) has gained much interest in schizophrenia research in the last years since it allows the non-invasive measurement of high- energy phosphates and phospholipids in vivo. We investigated hemispherical differences of the concentrations of different phosphorus compounds in the frontal lobes. For this purpose, well defined volumes in the dorsolateral prefrontal cortex of 32 healthy controls and 51 schizophrenic patients were examined. Schizophrenic patients showed significant lateralization effects of phosphodiesters (PDE) and the intracellular pH-value. Differences in the lateralization of 31P-MRS parameters between patients and healthy volunteers were only detected for the pH-value. While healthy controls exhibit lower pH-values in the left frontal lobe (6.96), in schizophrenic patients we found lower pH-values in the right (6.89). Detailed examinations showed that this effect is mainly based on the subgroup of schizophrenics who received atypical neuroleptic medication.
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Gabriele Huebner, Hans-Peter Volz, Stefan Riehemann, Berit Wenda, Grit Roessger, Reinhard Rzanny, Heinrich Sauer, "Lateralization effects of image-guided 31P magnetoresonance spectroscopic parameters in the frontal lobe of schizophrenics and healthy controls", Proc. SPIE 3660, Medical Imaging 1999: Physiology and Function from Multidimensional Images, (20 May 1999); doi: 10.1117/12.349613; https://doi.org/10.1117/12.349613
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