21 May 1999 Evaluation of renal function with contrast MRI: mathematical modeling and error analysis
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Dynamic MR imaging with contrast media is increasingly used to provide a safe and noninvasive assessment of renal function. Following intravenous injection of a paramagnetic tracer such as Gd-DPTA, the time course of MR signal is measured in arterial blood and in the kidneys. We use mathematical modeling and Monte Carlo trials to evaluate errors in computed renal parameters such as mean transit time (sigma) m as a function of injected dose. The model assumes that tracer concentration in the renal compartments is the result of convolution of the arterial curve and unit response functions. Results indicate that (sigma) m is not a monotonic function of the dose: instead it reaches a minimum for 2.5 - 3.5 ml of 500 mmol/l solution of Gd-DPTA and it rapidly increases for doses lower than 1 ml. These results can help optimize MR protocol and establish the feasibility of MR measurements using reduced doses of Gd-DPTA.
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Roza Rusinek, "Evaluation of renal function with contrast MRI: mathematical modeling and error analysis", Proc. SPIE 3661, Medical Imaging 1999: Image Processing, (21 May 1999); doi: 10.1117/12.348555; https://doi.org/10.1117/12.348555

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