New experimental results in atlas-based brain morphometry

James C. Gee; Brian A. Fabella; Siddharth E. Fernandes; Bruce I. Turetsky; Ruben C. Gur; Raquel E. Gur

doi:10.1117/12.348616

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21 May 1999 New experimental results in atlas-based brain morphometry

James C. Gee, Brian A. Fabella, Siddharth E. Fernandes, Bruce I. Turetsky, Ruben C. Gur, Raquel E. Gur

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Proceedings Volume 3661, Medical Imaging 1999: Image Processing; (1999) https://doi.org/10.1117/12.348616
Event: Medical Imaging '99, 1999, San Diego, CA, United States

Abstract

In a previous meeting, we described a computational approach to MRI morphometry, in which a spatial warp mapping a reference or atlas image into anatomic alignment with the subject is first inferred. Shape differences with respect to the atlas are then studied by calculating the pointwise Jacobian determinant for the warp, which provides a measure of the change in differential volume about a point in the reference as it transforms to its corresponding position in the subject. In this paper, the method is used to analyze sex differences in the shape and size of the corpus callosum in an ongoing study of a large population of normal controls. The preliminary results of the current analysis support findings in the literature that have observed the splenium to be larger in females than in males.

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James C. Gee, Brian A. Fabella, Siddharth E. Fernandes, Bruce I. Turetsky, Ruben C. Gur, and Raquel E. Gur "New experimental results in atlas-based brain morphometry", Proc. SPIE 3661, Medical Imaging 1999: Image Processing, (21 May 1999); https://doi.org/10.1117/12.348616

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