The US Army Aviation and Missile Command Missile Research, Development and Engineering Center has identified MEMS as an emerging technology with high potential for fulfilling the mission of future missiles. The technology holds the promise of reducing the size, weight, cost, and power requirements for performing existing functions in Army missile systems, as well las providing opportunities for new computing, sensing, and actuation functions that cannot be achieved with conventional electromechanical technology. MEMS will enable the Army's next generation of smaller and lighter missiles. The military market drives the thrust for development of miniature sensor with applications such as: competent and smart munitions, aircraft and missile autopilots, tactical missile guidance, fire control system, platform stabilization, smart structures with embedded inertial sensors, missile system health monitoring, missile and ground-based radar, radio frequency seekers, aerodynamic flow control, IR imagers, and multiple intelligent small projectiles. Current efforts at AMCOM include the development of MEMS-based inertial components to include accelerometers with wide dynamic range, tactical grade gyros with high rate range, and miniature three-axis inertial measurement unit with common interface electronics. Performance requirements of such components will be presented in terms of current and future Army missile systems. Additional MEMS based efforts under investigation at AMCOM include missile storage health monitoring, RF MEMS components, encoders for actuators, and aerodynamic flow control will also be discussed.