Cooperative response of keratinocytes and melanocytes to UV radiation during PUVA therapy

Mikhail M. Stolnitz; Pavel V. Baskakov; Anna Yu. Peshkova

doi:10.1117/12.341446

4 March 1999 Cooperative response of keratinocytes and melanocytes to UV radiation during PUVA therapy

Mikhail M. Stolnitz, Pavel V. Baskakov, Anna Yu. Peshkova

Proceedings Volume 3726, Saratov Fall Meeting '98: Light Scattering Technologies for Mechanics, Biomedicine, and Material Science; (1999) https://doi.org/10.1117/12.341446
Event: Saratov Fall Meeting '98: Light Scattering Technologies for Mechanics, Biomedicine, and Material Science, 1998, Saratov, Russian Federation

Abstract

The mathematical model of processes in UV-irradiated furocoumarin-sensitized epidermis is presented taking into account the mutual influence of keratinocytes and melanocytes populations. The model describes epidermis as a hierarchical structure on tissue (keratinocytes-melanocytes cooperation, melanin screen formation), cellular (proliferation and differentiation, transitions between subpopulations), subcellular (cell movement on mitotic cycle, generation, maturing and migration of melanosomes), and molecular (melanin synthesis, processes of DNA damage and repair, molecular signal transduction) levels.

Citation Download Citation

Mikhail M. Stolnitz, Pavel V. Baskakov, and Anna Yu. Peshkova "Cooperative response of keratinocytes and melanocytes to UV radiation during PUVA therapy", Proc. SPIE 3726, Saratov Fall Meeting '98: Light Scattering Technologies for Mechanics, Biomedicine, and Material Science, (4 March 1999); https://doi.org/10.1117/12.341446

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